General Hospital (1963– )


General Hospital (TV Series 1963– )

Events in this daytime drama are centered in Port Charles, a community on the coast in upper New York. On-going plots are centered around the people who work in General Hospital, people who work in the business community (most notably for the Quartermaines' company E.L.Q.), and some sort of international intrigue involving former Agents of the W.S.B. (World Security Bureau). Big plots of the past include Luke (Anthony Geary) and Laura's (Genie Francis') wedding and Mikkos Cassadine's (John Colicos') evil weather machine.
IMDb   6.5 /10
TheMovieDb    5.3 /10
FilmAffinity   4.2 /10
Creator Doris Hursley
Creator Frank Hursley
Release Date1963-04-01
Runtime1h 0min
GenreCrime, Drama, Romance
Content RatingTV-PG (TV-PG)
AwardsNominated for 1 Primetime Emmy. Another 295 wins & 637 nominations.
CompanyAmerican Broadcasting Company (ABC), American Broadcasting Company (ABC), Cinema Vehicle Services
Sonny Corinthos / ... 2,714 episodes, 1993-2021
Jason Morgan / ... 2,207 episodes, 1991-2021
Laura Wright
Laura Wright
Carly Corinthos / ... 2,126 episodes, 2005-2021
Sam McCall / ... 2,021 episodes, 2003-2021
Elizabeth Webber / ... 1,997 episodes, 1997-2021
Alexis Davis / ... 1,706 episodes, 1996-2021
Maxie Jones / ... 1,354 episodes, 2005-2021
Jasper 'Jax' Jacks 1,257 episodes, 1996-2021
Michael Corinthos / ... 1,165 episodes, 2010-2021
Dante Falconeri / ... 1,135 episodes, 2009-2021
Nikolas Cassadine / ... 1,134 episodes, 1996-2016
Dr. Patrick Drake / ... 1,133 episodes, 2005-2016

General Hospital

General Hospital (commonly abbreviated GH) is an American daytime soap opera. It is listed in Guinness World Records as the longest-running American soap opera in production, and the second in American history after Guiding Light. Concurrently, it is the world's third longest-running scripted drama series in production after British serials The Archers and Coronation Street, as well as the world's second-longest-running televised soap opera still in production. General Hospital premiered on the ABC television network on April 1, 1963. General Hospital is the longest-running serial produced in Hollywood, and the longest-running entertainment program in ABC television history. It holds the record for most Daytime Emmy Awards for Daytime Emmy Award for Outstanding Drama Series, with 13 wins.

The show was created by husband-and-wife soap writers Frank and Doris Hursley, who originally set it in a hospital (hence the title), in an unnamed fictional city. In the 1970s, the city was named Port Charles, New York. From its beginning, General Hospital starred John Beradino and Emily McLaughlin, and both actors stayed with the show until their deaths in 1996 and 1991, respectively. They were joined a year later by Rachel Ames who remains to date the longest serving actress on an ABC soap opera, having been continuously on the show from 1964 to 2007. General Hospital was the second soap to air on ABC (after the short-lived Road to Reality, which aired for several months during the 1960–61 season). In 1964, a sister soap was created for General Hospital, The Young Marrieds; it ran for two years, and was canceled because of low ratings. General Hospital also spawned the daytime series Port Charles (1997–2003) and the primetime spin-off General Hospital: Night Shift (2007–2008). Taped at The Prospect Studios, General Hospital aired for a half-hour until July 23, 1976. The series was expanded from 30 minutes to 45 minutes on July 26, 1976, and then to a full hour on January 16, 1978.

Ever since the late 1970s, most of the storylines have revolved around the Quartermaine family and the Spencer family. From 1979 to 1988, General Hospital had more viewers than any other daytime soap opera. It rose to the top of the ratings in the early 1980s in part thanks to the monumentally popular "supercouple" Luke and Laura, whose 1981 wedding brought in 30 million viewers and remains the highest-rated hour in American soap opera history. The soap opera is also known for its high-profile celebrity guest stars who have included, among others, Roseanne Barr, James Franco and Elizabeth Taylor. In 2007, the program was listed as one of Time magazine's "100 Best TV Shows of All-TIME". On April 23, 2009, General Hospital began broadcasting in high-definition television, making it the first ABC soap opera to make such a transition. The serial aired its 14,000th episode on February 23, 2018.

General Hospital became the oldest American soap opera on September 17, 2010, following the final broadcast of CBS' As the World Turns. On April 14, 2011, ABC announced the cancellation of both All My Children and One Life to Live, leaving General Hospital as the last remaining soap opera airing on the network after January 13, 2012. The show celebrated its 50th anniversary on April 1, 2013.

Show history


General Hospital was created by Frank and Doris Hursley and premiered on April 1, 1963. The first stories were mainly set on the seventh floor of General Hospital, in an unnamed midsize Eastern city (the name of the city, Port Charles, would not be mentioned until the late 1970s). "They had this concept of the show that it was like a big wagon wheel – the spokes would be the characters and the hub would be the hospital," John Beradino (Steve Hardy) later reflected to Entertainment Weekly in 1994.


Launched in 1963, the first stories were mainly set at General Hospital in an unnamed midsized Eastern city. The name of the city, Port Charles, would not be mentioned until 1976 by headwriters Eileen and Robert Mason Pollock. Storylines revolved around Steve Hardy (John Beradino) and his friend, Nurse Jessie Brewer (Emily McLaughlin). Jessie's turbulent marriage to the much-younger Phil Brewer (originally portrayed by Roy Thinnes; lastly by Martin West) was the center of many early storylines. In 1964 Audrey Hardy (Rachel Ames), a flight attendant and sister of Nurse Lucille (Lucille Wall), came to town, and was the woman who won Steve's heart.

By the end of the 1970s, General Hospital was facing dire ratings when executive producer Gloria Monty was brought in to turn the show around. Monty is credited with creation of the first supercouple, Luke and Laura, played by Anthony Geary and Genie Francis. The end of their hour wedding on November 17, 1981, was the most-watched event in daytime serial history. During the 1980s, the series featured several high-profile action, adventure, and some science fiction-based storylines. Location shooting at sites including Mount Rushmore in South Dakota; Niagara Falls; Grand Ole Opry in Nashville, Tennessee; Atlantic City, New Jersey; Big Bear and Avalon (Catalina Island), California; and San Antonio, Texas are some that propelled the story.

After Gloria Monty first left the series in 1987, General Hospital entered into a transitional phase that lasted until Wendy Riche took the position of executive producer in 1992. Under Riche, the show gained critical acclaim for its sensitive handling of social issues. In 1994, Riche started an annual Nurses' Ball, a fundraiser and HIV/AIDS awareness event both on the show and in real life. Later that year, a heart transplantation storyline involves the death of eight-year-old B. J. Jones (daughter of Dr. Tony Jones and Bobbie Spencer) in a bus crash and the subsequent donation of her heart to her dying cousin Maxie Jones. Shortly afterwards, Monica Quartermaine (Leslie Charleson) begins a long battle with breast cancer, which leads to her adopting Emily Quartermaine, the orphaned young daughter of Monica's friend from treatment. General Hospital was also praised for the love story of teenagers Stone Cates (Michael Sutton) and Robin Scorpio (Kimberly McCullough). After a struggle that lasted throughout most of 1995, Stone dies from AIDS at the age of 19 and his death is followed by 17-year-old Robin having to deal with being HIV-positive as a result of their relationship. Sutton received a nomination for the Daytime Emmy Award for Outstanding Supporting Actor in a Drama Series and McCullough won an Daytime Emmy Award for Outstanding Younger Actress in a Drama Series award. ABC featured an Afterschool Special "Positive: A Journey Into AIDS" revolving around the AIDS story as well as The New York Times best selling novel Robin's Diary.

On Saturday, December 14, 1996, General Hospital aired its one of three primetime episodes, General Hospital: Twist of Fate, which picked up where that Friday's episode had left off. The special centered on Laura's supposed death at the hands of Stefan Cassadine. In 1997, the show's long-rumored spin-off materialized into the half-hour serial, Port Charles. The series' 11,000th episode aired on February 20, 2006. On April 23, 2009, General Hospital became ABC's first regular daytime drama to be taped and broadcast in High-definition television, though the 2008 season of its primetime spinoff General Hospital: Night Shift was in high definition. This is the second daytime drama to move to high definition after CBS's The Young and the Restless. On February 23, 2010, the series aired its 12,000th episode. On December 1, 2011, ABC confirmed that former One Life to Live executive producer Frank Valentini and head writer Ron Carlivati would replace longtime executive producer Jill Farren Phelps and Garin Wolf respectively, though Wolf would remain on as a regular writer. The change took effect on January 9, 2012. The first episode under the direction of Valentini aired on February 1, 2012, and Carlivati's material started airing on February 21, 2012. Several storylines reminiscent of iconic story arcs of the past were created and popular characters returned to the show in order to commemorate the 50th anniversary of the series in 2013. The serial celebrated 13,000 episodes on February 24, 2014, and marked its 51st anniversary on April 1, 2014. Also in January 2014, ABC renewed Carlivati's contract with the soap. The series marked its 52nd anniversary on April 1, 2015, with a special episode revolving around the Spencer family.

In July 2015, it was revealed that Carlivati was fired as Head Writer, with Shelly Altman and Jean Passanante rehired as replacements. On September 16, 2016, Daytime Confidential reported that Valentini, Passanante and Altman re-signed with the show. On June 6, 2017, Passanante announced her decision to retire from the serial. On July 29, 2017, it was revealed through Passanante that breakdown writer Chris Van Etten will be promoted to co-head writer along with Altman as her replacement. On February 23, 2018, the serial aired its 14,000th episode. On July 30, 2019, it was announced that Altman would retire; breakdown writer Dan O'Connor was announced as her successor, joining Van Etten as co-head writer.

Production summary

General Hospital has aired on the ABC television network and has been filmed in Hollywood since its inception. The show was filmed in the Sunset Gower Studios from 1963 to the mid-1980s. It relocated in the 1980s to The Prospect Studios, where it remains.

General Hospital has had a number of different distributors throughout the show's history. From its beginning until 1968, it was a co-production of Plitt Theatres and Selmur Productions. ABC bought the series outright in 1968 and its ownership passed from Selmur to American Broadcasting Companies, Inc., ABC's old separate conglomerate. Ownership of the soap was then passed when the original ABC, Inc. merged with Capital Cities/ABC Inc. in 1985 and it became Capital Cities/ABC, Inc. The show would change hands again when The Walt Disney Company bought Capital Cities/ABC in 1996 and Disney began to program the network and the soap in September 1997 where it remains today.

Production of General Hospital was suspended in March 2020, as a direct result of the COVID-19 pandemic in the United States. Production resumed on July 22 of the same year; new episodes began airing on August 3, 2020.


Original cast
Cynthia AllisonCarolyn Craig
Jessie BrewerEmily McLaughlin
Dr. Phil BrewerRoy Thinnes
Angie CostelloJana Taylor
Mike CostelloRalph Manza
Fred FlemingSimon Scott
Janet FlemingRuth Phillips
Dr. Steve HardyJohn Beradino
Roy LansingRobert Clarke
Priscilla LongworthAllison Hayes
Dr. Ken MartinHunt Powers
Peggy MercerK. T. Stevens
Philip MercerNeil Hamilton
Mrs. WeeksLenore Kingston
Al WeeksTom Brown
Eddie WeeksCraig Curtis


Though the series originally focused on solely the medical staff at Port Charles' General Hospital, and starred John Beradino as Dr. Steve Hardy and Emily McLaughlin as Nurse Jessie Brewer, the series branched out and began to focus more on the people and families of the town of Port Charles rather than those solely in the hospital.

Port Charles is full of "dysfunctional family dynamics...and family drama remains the focal point of this town." The current families on the show include the quarreling and wealthy Quartermaine family, the mobster crime Corinthos family, the middle class Scorpio/Jones family, the aristocratic Cassadine family, and the adventurous Spencer family.

Main crew members

  • Executive producer: Frank Valentini
  • Producers: Michelle Henry (senior producer), Mary-Kelly Weir (senior producer), Jennifer Whittaker-Brogdon (producer), Nneka Garland (coordinating producer), Jeffrey Sierks (associate producer)
  • Directors: Larry Carpenter, Tina Keller, William Ludel, Scott McKinsey, Gary Tomlin, Frank Valentini, Denise Van Cleave, Phideaux Xavier
  • Head writers: Dan O'Connor and Chris Van Etten
  • Associate head writer: Anna Theresa Cascio
  • Breakdown writers: Barbara Bloom, Suzanne Flynn, Lloyd Gold, CJ Hoke, Elizabeth Korte
  • Script writers: Charlotte Gibson, Kate Hall, Lisa Seidman, Donny Sheldon, Scott Sickles
  • Casting director: Mark Teschner, Lisa Booth (casting associate)
  • Lighting directors: Bob Bessoir, Melanie Mohr, Vincent Steib

Former notable crew members: Gloria Monty, Jill Farren Phelps, Robert Guza Jr., Charles Pratt Jr., John William Corrington, Lewis Arlt, Lynda Myles, Alan Pultz, Judith Pinsker, Joseph Behar, Stephanie Braxton, Norma Monty, Frank South, Ralph Ellis, Shelley Curtis, Jean Passanante, Hope Harmel Smith, Michael Conforti, Michele Val Jean and Ron Carlivati.

Executive producers

General Hospital executive producers
Selig J. Seligman1963
James Young1963–75
Tom Donovan1975–77
Gloria Monty1978–87, 1991–92
H. Wesley Kenney1987–89
Joseph Hardy1989–91
Wendy Riche1992–2001
Jill Farren Phelps2001–12
Frank Valentini2012–present


Since the series began in 1963, Port Charles, New York, has been the setting for the show. The town exists in the same fictional universe as other soap opera settings such as Llanview (One Life to Live), Pine Valley (All My Children), New York City (Ryan's Hope), and Corinth (Loving). The same setting was also used for the show's spinoff Port Charles.

  • General Hospital is founded by Dr. Steve Hardy. It is a major employer in the city, and one of the largest medical facilities on the East Coast. In the 1990s, Sonny Corinthos donates an extra wing dedicated to AIDS research, and in the 2000s, Carly Corinthos donates a pediatric center for head neurology. In 2009, a fire destroys the hospital, which is rebuilt with money from the Quartermaine family.
  • The Metro Court is a prominent hotel in Port Charles, built by Jasper Jacks on the site of the Port Charles Hotel after it is destroyed in a fire in 2004, and named in honor of Courtney Matthews who Jax was pursuing romantically. Carly Corinthos soon becomes his business partner, and later co-owns with Kate Howard when Jax sells his portion to her. The hotel boasts a skyline restaurant, spa, penthouse suites, and business offices. The current owners are Carly and Olivia Falconeri.
  • Kelly's Diner is founded by Joe "Paddy" Kelly, and becomes a vintage restaurant in the heart of Port Charles. It features boarding rooms upstairs which become homes to many Port Charles residents and guests over the years. The restaurant is operated by Paddy's wife Rose Kelly after his death, who later sells it to Ruby Anderson when Rose leaves town. When Ruby dies, she leaves the diner to her niece Bobbie Spencer and nephew Luke Spencer.
  • The Haunted Star is a yacht first owned by Luke Spencer, who receives the vessel as a wedding present in 1981. In 2003, the ship is turned into a casino by Luke and investors Skye Chandler and Tracy Quartermaine. In 2011, Luke's daughter Lulu Spencer purchases the boat, and in 2012 Johnny Zacchara invests to become co-owner. Together they turn the ship into a nightclub.
  • The Floating Rib is a bar located in downtown Port Charles, just a block away from General Hospital. Originally named Jake's, the bar has been a hotspot for the local nightlife since the early 1990s. Coleman Ratcliffe becomes the owner in 2002, and Mac Scorpio takes over in 2012. There was also a popular fine dining restaurant in Port Charles with the same name in the late 1970s / early 1980s. In 2020, a bomb explosion destroys the restaurant and kills multiple patrons.

Accolades and recognition

General Hospital's cast and crew have won many awards since 1974 when the Daytime Emmy Awards were created. In 2012, the Creative Arts Emmy Awards were created. General Hospital has won 13 Daytime Emmy's for Daytime Emmy Award for Outstanding Drama Series.

In June 2009, TV Guide ranked "Luke and Laura's Wedding" #45 on its list of the 100 Greatest Episodes.

Broadcast history

During the 1960s, General Hospital earned decent ratings against the likes of To Tell the Truth and The Secret Storm on CBS, but there was a decline as the 1970s came, especially when NBC's Another World became highly popular. For two years, it also faced CBS' The Price Is Right, already a major hit. After continued mediocrity in the Nielsen ratings, ABC was prepared to cancel General Hospital, but decided to give it a second chance in 1978 when it expanded the show to a full hour, from an experimental 45 minutes. However, the expansion came with an ultimatum to the producers that they had six months to improve the show's ratings. Gloria Monty was hired as the new executive producer, and on her first day, she spent an extra $100,000 re-taping four episodes. A miracle occurred thanks to Monty and head writer Douglas Marland; the show became the most watched daytime drama by 1979, marking a rare instance of a daytime serial's comeback from near-extinction. During the wedding of Luke and Laura on November 17, 1981, about 30 million people tuned in to watch them exchange vows and be cursed by Elizabeth Taylor's Helena Cassadine (Constance Towers).

From 1979 to 1988, General Hospital remained number one in the ratings, competing against two low-rated soaps on NBC—Texas and Santa Barbara—and Guiding Light on CBS (although Guiding Light experienced a renaissance for a brief period in the middle of 1984, and became the #1 rated soap, briefly dethroning General Hospital from the top ratings spot). For the most part, however, General Hospital continued to triumph, even after the departure of popular actors Anthony Geary and Genie Francis in the mid-1980s. Although The Young and the Restless took General Hospital's place as the highest-rated serial in 1989, General Hospital continued to maintain excellent ratings.

Even at its peak in the 1980s, General Hospital had been pre-empted in at least two markets in the United States. With the show still number one in the Nielsens, WDTN in Dayton, Ohio pre-empted the series upon joining ABC in January 1980 in favor of Woody Woodpecker and Super Friends cartoons. Later, the station would air such shows as Hour Magazine, Geraldo and Maury in the show's time slot until September 2000, when the station's new owners, Sunrise Broadcasting (which purchased the station from Hearst Television two years prior), pulled Maury from the station's schedule, due to what it called "community standards", and brought General Hospital back to Dayton. In Vermont and Plattsburgh, WVNY dropped General Hospital from the schedule in the 1980s and would only bring it back in 1995. During that hiatus, General Hospital still aired on Montreal's CFCF-DT, whose signal was decently available in Vermont and Plattsburgh.

Ever since the 1991–1992 season of General Hospital, the show has had a steady decline in ratings. On and off, it would rank between third and fifth place in the Nielsen ratings, with CBS's The Young And The Restless and The Bold and the Beautiful coming in first and second place, respectively. General Hospital remained in between third and fifth place in the ratings during that time and from late 1991 to 1996 All My Children held the title of ABC's highest rated soap. During the 1990s General Hospital was put up against competition such as CBS's As the World Turns and NBC's Days of Our Lives although neither show aired at the same time as General Hospital.

After months of speculation and cancellation rumors, Deadline Hollywood reported on April 11, 2012, that ABC quietly made the decision to keep General Hospital on the air and to cancel instead the lower-rated talk show The Revolution. On June 26, 2012, ABC officially announced that General Hospital would move to the 2 p.m. ET/PT timeslot starting on September 10, 2012, and that it would give the 3:00 p.m. hour back to its affiliates, as it was the recommended time slot for Katie Couric's new, ABC-syndicated talk show, Katie.

Encore episodes were shown every weeknight on the former cable channel Soapnet, with a marathon on Saturday and classic episodes at 4 A.M. EST and 5 A.M. (3.AM, 4 A.M. CST).

Production of General Hospital was suspended in March 2020 as a direct result of the COVID-19 pandemic in the United States. The show had banked roughly two months worth of episodes at that time. By airing repeats on "Flashback Fridays", General Hospital was able to air original episodes through the end of May 21, 2020. This will be followed by several weeks of vintage episode repeats. Production resumed on July 22, 2020 and new episodes began airing on August 3, 2020.


General Hospital broadcast history
Start dateEnd dateTime slot
Eastern Time Zone/Central Time Zone)
Run time
April 1, 1963December 27, 19631:00 pm/12 noon30
December 30, 1963July 23, 19763:00 pm/2:00 pm
July 26, 1976January 13, 19783:15 pm/2:15 pm45
January 16, 1978September 7, 20123:00 pm/2:00 pm60
September 10, 2012Present2:00 pm/1:00 pm1

ABC stations in the Mountain and Pacific Time Zones, and in Alaska and Hawaii follow a Central Time Zone schedule for daytime programming; thus, General Hospital is scheduled by the network to air at 1:00 pm in these areas.

Ratings history

For historical ratings information, see List of U.S. daytime soap opera ratings

General Hospital ratings history
Year(s)Household Rating
1987–19888.1 (Tied with The Young and the Restless)
General Hospital ratings history
SerialHousehold rating(Time slot) NetworkMillions of households
1. General Hospital16.0(3-4pm) ABC17.5
2. All My Children10.2(1-2pm) ABC11.7
3. One Life to Live10.2(2-3pm) ABC11.6
4. Guiding Light7.9(3-4pm) CBS8.2

Cultural influence

Parodies and references in other media

The popularity of General Hospital has gained it many parodies and references in other mainstream programs. For example:

  • In the early 1990s, some episodes of General Hospital were featured as "shorts" during the fourth season of the parody show Mystery Science Theater 3000.
  • The series was also parodied/homaged in the song "General Hospi-Tale" by The Afternoon Delights, and in the film Tootsie, which took place among the cast and crew of a fictional soap opera program.
  • In the Fox medical drama House, Gregory House enjoys Prescription: Passion, which is an over-the-top parody of General Hospital that he watches constantly. In the season three episode, "Half-Wit", House hides his blood test results under the name, "Luke N. Laura", referring to General Hospital's legendary couple.
  • Mad TV did a sketch on the series with actors Jacklyn Zeman, Rebecca Herbst, and Jacob Young.
  • The movie Young Doctors in Love featured a large part of General Hospital's cast from 1982.
  • In a 2010 episode of The Colbert Report, comedian Stephen Colbert poked fun at the show, responding to a clip of Maurice Benard's Sonny Corinthos shooting Dominic Zamprogna's Dante Falconeri, satirically screaming, "Sonny shot Dante! No!"
  • In the hit TV show The Goldbergs, Erica and Adam frequently watch General Hospital together.
  • In the book series Virgin River by Robyn Carr, Mel mentions watching General Hospital in nursing school.

Famous fans

This section appears to contain trivial, minor, or unrelated references to popular culture. Please reorganize this content to explain the subject's impact on popular culture, providing citations to reliable, secondary sources, rather than simply listing appearances. Unsourced material may be challenged and removed. (August 2020)

General Hospital has many famous fans, including:

  • Wayne Gretzky and his wife, Janet Jones
  • The Sopranos actor Vincent Pastore, who joined the show in late 2008 for a short guest stint
  • World-renowned skier Kristi Leskinen is a devout fan of the show
  • Actor Jason Gray-Stanford
  • Singer Billy Currington.
  • Freestyle motocross rider Mike Metzger is also a fan of the program and rarely misses an episode.
  • Elizabeth Taylor was a part of Luke and Laura's 1981 wedding, and joined the cast temporarily as the originating Helena Cassadine.
  • Diana, Princess of Wales was a devout fan of the show, and went as far as to send two bottles of Bollinger champagne to Anthony Geary and Genie Francis in time for Luke and Laura's 1981 wedding. Geary turned his into a lamp.
  • General Hospital helped launch the singing career of Rick Springfield, who had watched the show for many years before joining the series in 1981.
  • Comedian Jimmy Pardo frequently refers to his fandom on his podcast Never Not Funny, and has had stars of the show such as Jack Wagner, Carolyn Hennesy, and Jason Thompson on the podcast as guests.

Spin-offs and specials

The success of the long-running soap opera has had one sister serial, one spinoff in the United States, and two primetime spinoffs in the United States and the United Kingdom.

The Young Marrieds was ABC's first attempt at a sister serial for General Hospital. It ran for only two years, racking up a total of 380 episodes. Despite its moderate popularity, it was aired against CBS's top-rated The Edge of Night, which it could not compete against. The series finale aired on March 25, 1966, with the show's main protagonist contemplating suicide. It ended in a cliffhanger, leaving the audience wondering if the man had killed himself or not. The Young Marrieds was set in the fictional suburb of Queen's Point, which was considered by the writers to be a suburb of Port Charles.

The British television series General Hospital did not feature any characters from the American show, but was modeled after its format. It started as a half-hour program broadcast in the afternoons, which was unusual for British serials that normally aired in prime time. In 1975, it was expanded to an hour-long format and moved to Friday evenings.

Port Charles was a daytime drama that initially featured interns in a competitive medical school program, and was known for having more action actually in the hospital than General Hospital itself. It also included the characters of Scott Baldwin, Serena Baldwin, Lucy Coe, Kevin Collins, and Karen Wexler, all of whom originally appeared as characters on General Hospital. As the show evolved, it tended more towards gothic intrigue, including supernatural elements such as vampires and afterlife. It also switched formats from an open-ended daytime serial to 13-week story arcs known as "books", similar to Spanish language telenovelas.

General Hospital: Night Shift is the second American prime time spinoff of a daytime drama (the first being Our Private World, a spinoff of As the World Turns). Its first season aired from July 12, 2007, to October 4, 2007, on Soapnet, a cable channel owned by ABC. The series follows the nighttime adventures of familiar and new characters around the hospital. As of March 2008, the first season of the series was "Soapnet's most-watched series ever", with ABC Daytime and Soapnet President Brian Frons noting that Night Shift drew more than 1 million new viewers to the channel during its first season.

General Hospital: Twist of Fate was a primetime special that aired on Saturday, December 14, 1996. The episode picked up where that Friday's show had left off. The special centered on Laura's supposed death at the hands of Stefan Cassadine.

On April 2, 1998, General Hospital aired a primetime special in celebration of the program's 35th anniversary. Hosted by Anthony Geary, the show focused and recapped on many popular storylines including Monica Quartermaine's breast cancer, BJ's death, and Stone Cates' battle with HIV. This was the first anniversary special that was broadcast in primetime and that didn't include any of the current storyline.

On April 6, 2013, as part of the show's 50th anniversary commemoration, ABC's newsmagazine 20/20 aired General Hospital: The Real Soap Dish—a retrospective and behind-the-scenes special hosted by Katie Couric.

On September 5, 2014, it was announced that cast member Nancy Lee Grahn would begin to host a companion web series for in January 2015, General Hospital Now!, which would feature behind-the-scenes interviews with fellow cast members, as well as panel discussions with comedians who are fans of the show.

On May 15 and 18, 2015, General Hospital aired two live episodes as part of its 52nd anniversary celebration, using the hashtag #GHLive to promote the broadcast on social media.