 | Kimberly McCullough | Dr. Robin Scorpio 27 episodes, 2007-2008 |
 | Jason Thompson | Dr. Patrick Drake 27 episodes, 2007-2008 |
 | Sonya Eddy | Epiphany Johnson, R.N. 25 episodes, 2007-2008 |
 | Billy Dee Williams | Touissant DuBois / ... 25 episodes, 2007-2008 |
 | Richard Gant | Dr. Russell Ford 14 episodes, 2007-2008 |
 | Azita Ghanizada | Dr. Saira Batra 14 episodes, 2008 |
 | Adam Grimes | Dr. Kyle Julian 14 episodes, 2008 |
 | Iman Nazemzadeh | Dr. Leo Julian / ... 14 episodes, 2008 |
 | Antonio Sabato Jr. | Jagger Cates 14 episodes, 2008 |
 | Carrie Southworth | Dr. Claire Simpson 14 episodes, 2008 |
 | Steve Burton | Jason Morgan 13 episodes, 2007 |
 | Bradford Anderson | Damien Spinelli 13 episodes, 2007 |
 | Amanda Baker | Jolene Crowell 13 episodes, 2007 |
 | Nazanin Boniadi | Leyla Mir 13 episodes, 2007 |
 | Kent King | Dr. Lainey Winters 13 episodes, 2007 |
 | Minae Noji | Kelly Lee / ... 13 episodes, 2007 |
 | Dominic Rains | Dr. Leo Julian 13 episodes, 2007 |
 | Angel M. Wainwright | Regina Thompson 13 episodes, 2007 |
 | Ron Melendez | Dr. Andy Archer 13 episodes, 2007 |
 | Graham Shiels | Cody Paul 13 episodes, 2007 |
 | Hadeel Sittu | Barrett 13 episodes, 2007 |
 | Tristan Rogers | Robert Scorpio 12 episodes, 2008 |
| | David Tran | Orderly 9 episodes, 2007 |
 | Wendy Braun | Ms. Iris Sneed 8 episodes, 2007 |
| | Erica Ellis | Heather 7 episodes, 2007 |
 | Cameron Boyce | Michael 'Stone' Cates Jr. 7 episodes, 2008 |
 | John J. York | Malcolm 'Mac' Scorpio 6 episodes, 2007-2008 |
 | James Harper | Jordan Lovell 6 episodes, 2007 |
 | Kirsten Storms | Maxie Jones 5 episodes, 2007 |
 | Alla Korot | Stacy Sloan / ... 5 episodes, 2007 |
 | Chad Allen | Eric Whitlow 5 episodes, 2008 |
 | Timothy Slaske | Cop 4 episodes, 2007-2008 |
| | Oscar Arana | Doctor 4 episodes, 2007 |
 | Rick Fitts | Roger Winters 4 episodes, 2007 |
 | Marilyn McIntyre | Lori Thompson 4 episodes, 2007 |
 | Finola Hughes | Anna Devane 4 episodes, 2008 |
| | Kiko Ellsworth | Stan Johnson 3 episodes, 2007 |
 | Wendy Pennington | Sophia 3 episodes, 2007-2008 |
 | Nathan Anderson | Curtis Reitzel 3 episodes, 2007 |
 | Danny Arroyo | Pablo Garcia 3 episodes, 2007 |
 | Pat Crawford Brown | Mrs. Storch 3 episodes, 2007 |
 | Chrissie Fit | Lupe Rosales 3 episodes, 2007 |
 | Edwin Gonzalez | Javy 3 episodes, 2007 |
 | Rebecca Herbst | Elizabeth Webber Spencer 3 episodes, 2007 |
 | Ray Proscia | Sanders / ... 3 episodes, 2007 |
| | Jae Toyota | Nurse 3 episodes, 2007 |
| | Laura Lyman | Anesthesiologist / ... 3 episodes, 2008 |
 | David Pearl | Doctor 3 episodes, 2008 |
 | Patrick Viall | Intern #1 / ... 1 episode, 2007-2008 |
 | Adrian Alvarado | Detective Cruz Rodriguez 2 episodes, 2007 |
 | Jesse C. Boyd | Jared Moore 2 episodes, 2007 |
 | Molly Cheek | Marion Moore 2 episodes, 2007 |
 | Christopher Curry | Jared's Father 2 episodes, 2007 |
 | Jason Gerhardt | Coop Barrett / ... 2 episodes, 2007 |
| | Reign Morton | Young Toussaint 2 episodes, 2007 |
| | Alan Bovinett | Doctor 2 episodes, 2008 |
 | Leslie Charleson | Dr. Monica Quartermaine 2 episodes, 2008 |
 | Anthony Geary | Luke Spencer 2 episodes, 2008 |
 | Sean Hampton | Orderly 1 episode, 2008 |
| | Heather Hudson | Intern 2 episodes, 2008 |
 | James Jurdi | Patient 2 episodes, 2008 |
 | John Reilly | Sean Donely 2 episodes, 2008 |
 | Toni Sawyer | Mrs. Whitlow 2 episodes, 2008 |
 | Joshua Snyder | Ryan McCormick 2 episodes, 2008 |
| | Sharon Wyatt | Tiffany Hill Donely 2 episodes, 2008 |
 | Elena Schuber | Penny Kaseoff 1 episode, 2007 |
| | Chris Ingersoll | Nate Kaseoff 1 episode, 2007 |
 | Julie Berman | Lulu Spencer 1 episode, 2007 |
| | Ladae Bond | Michelle 1 episode, 2007 |
| | Megan Briones | Pregnant Woman 1 episode, 2007 |
 | Laura Buckles | Woman 1 episode, 2007 |
 | Derk Cheetwood | Max Giambetti 1 episode, 2007 |
 | Michael David Cheng | Morgue assistant 1 episode, 2007 |
| | Tico Clark | Officer 1 episode, 2007 |
 | Claudia DiMartino | Woman 1 episode, 2007 |
 | Christopher M. Dukes | E.R. Patient 1 episode, 2007 |
 | Kris Frost | Intern 1 episode, 2007 |
| | Justin Rodgers Hall | Dr. Hall 1 episode, 2007 |
| | Malachi Haynes | Young Leland 1 episode, 2007 |
 | Carolyn Hennesy | Diane Miller 1 episode, 2007 |
 | Peter James | Jolene Crowell's father 1 episode, 2007 |
| | Amanda Jones | Baby Jake 1 episode, 2007 |
| | Maryssa Jones | Baby Jake 1 episode, 2007 |
| | Miranda Jones | Baby Jake 1 episode, 2007 |
 | Michele Karpel | 1 episode, 2007 |
 | Lindze Letherman | Georgie Jones 1 episode, 2007 |
| | Gene Mitchell | Doctor #1 1 episode, 2007 |
 | Nina Nayebi | Mrs Noorani 1 episode, 2007 |
 | Christopher Neiman | Norman Minx 1 episode, 2007 |
 | Eric Poppick | 1 episode, 2007 |
 | Ryan Preimesberger | Doctor 1 episode, 2007 |
 | Vanessa Robertson | Head Nurse 1 episode, 2007 |
| | Cindy Sawyer | Nurse #1 1 episode, 2007 |
 | Stewart Skelton | Dr. Flax 1 episode, 2007 |
 | Dan Southworth | Attendant / ... 1 episode, 2007 |
 | Nikki Tyler-Flynn | Christine 1 episode, 2007 |
 | Larry Varanelli | Security Guard 1 episode, 2007 |
 | Mark Anthony Vazquez | Police Officer 1 episode, 2007 |
 | Peter Allen Vogt | Clown 1 episode, 2007 |
 | Roy Vongtama | Dr.Boyd 1 episode, 2007 |
 | Audrey Wasilewski | Sondra Minx 1 episode, 2007 |
 | Rick Williamson | X-Ray Tech 1 episode, 2007 |
 | Cynthia Youngblood | Surgical Nurse 1 episode, 2007 |
 | Sam Zeller | Mechanic 1 episode, 2007 |
 | Vinicius Zorin-Machado | Jimmy - gang banger 1 episode, 2007 |
 | Michael Antosy | 1 episode, 2008 |
| | Blaise Baker | Kayla 1 episode, 2008 |
 | Neill Barry | Will 1 episode, 2008 |
| | Laura Bottrell | Alice 1 episode, 2008 |
 | Jeanette Brox | Moira 1 episode, 2008 |
 | Ellen Bry | Maggie 1 episode, 2008 |
 | Amanda Carlin | Mrs. Hopkins 1 episode, 2008 |
| | Heather Ashley Chase | Dr. Amanda Julian 1 episode, 2008 |
 | Rose Colasanti | Nurse Anderson 1 episode, 2008 |
 | Marcus Collins | James Buckley 1 episode, 2008 |
| | Evette Cord | Wounded Civilian 1 episode, 2008 |
| | Sheridan Crist | Skinhead 1 episode, 2008 |
 | Doug DeBeech | Larry / ... 1 episode, 2008 |
 | Mark DeLisle | Cop #1 1 episode, 2008 |
 | Valerie Dillman | Leah Walker 1 episode, 2008 |
| | M. Devon Dunlap | Medical Intern 1 episode, 2008 |
| | Doug Eakins | Orderly 1 episode, 2008 |
 | Candace Edwards | Doner 1 episode, 2008 |
 | Jen Eldridge | Nurse Isabelle 1 episode, 2008 |
 | Christine Elise | Sylvia 1 episode, 2008 |
 | Annie Fitzgerald | Yvette 1 episode, 2008 |
 | Michael Fucci | Phil 1 episode, 2008 |
 | Laura Gardner | Valerie 1 episode, 2008 |
 | Craig Gellis | Trent 1 episode, 2008 |
 | Joey Gray | Elisa's Roomate 1 episode, 2008 |
| | Lee Gale Gruen | Sexy Senior Woman 1 episode, 2008 |
 | Reamy Hall | Alison 1 episode, 2008 |
 | Scott Healy | FBI Agent 1 episode, 2008 |
 | Merritt Hicks | Danielle Forrester 1 episode, 2008 |
 | Jared Hillman | Cyrus 1 episode, 2008 |
 | Anne Marie Howard | Nicole 1 episode, 2008 |
 | Joe Howard | Frank Deerborn 1 episode, 2008 |
| | Paul Keith | Senior Citizen 1 episode, 2008 |
 | Rick Kelly | Gary 1 episode, 2008 |
 | Dylan Kenin | Chad 1 episode, 2008 |
| | Craig LaMarsh | Orderly 1 episode, 2008 |
 | Claire Lanay | Robert Scorpio's nurse 1 episode, 2008 |
 | Cheselka Leigh | Elisa 1 episode, 2008 |
 | Bunny Levine | Estelle Lambert 1 episode, 2008 |
 | Emily Liu | Grace 1 episode, 2008 |
 | Macklen Makhloghi | Guard #1 1 episode, 2008 |
 | P.J. Marino | Nick Costa 1 episode, 2008 |
 | Nick McCallum | Jerry 1 episode, 2008 |
| | Melissa McCrone | Screaming Victim 1 episode, 2008 |
| | Sarah McMaster | Intern 1 episode, 2008 |
 | Daver Morrison | Injured Man (Will) 1 episode, 2008 |
 | Kathleen Noone | Patricia Julian 1 episode, 2008 |
| | Chris Payne | FBI Agent 1 episode, 2008 |
 | Robert Pine | Mr. Whitlow 1 episode, 2008 |
 | David Pires | Process Server 1 episode, 2008 |
| | Eileen Rogers | Nursing Mother 1 episode, 2008 |
| | Christine Romeo | Natalie 1 episode, 2008 |
| | Todd Royal | Guard 1 episode, 2008 |
 | Greg Siff | Bobby Duncan 1 episode, 2008 |
 | Chris Smith | 1 episode, 2008 |
| | Erik Stahl | X Ray Guy 1 episode, 2008 |
 | Jeffrey Stubblefield | Roger Walker 1 episode, 2008 |
 | Greg Wayne | Alan Skinner 1 episode, 2008 |
| | Lori Weber | Nurse 1 episode, 2008 |
 | Annette Marie Westwood | Groom's Sister 1 episode, 2008 |
| | Gregory White | Dean Byron 1 episode, 2008 |
 | Rachel Winfree | Mrs. Byron 1 episode, 2008 |
| | Clay Nicholas Woods | FBI Agent 1 episode, 2008 |
| | Kathryn Farren | Nurse in Nursery (uncredited) unknown episodes |
 | Maurice Benard | Sonny Corinthos (uncredited) unknown episodes |
| | Danny Logan | Patient #3 (uncredited) unknown episodes |
 | Preston James Hillier | Joey (uncredited) unknown episodes |
| | Corinna La Rocco | ER Nurse (uncredited) unknown episodes |
